Though hippocampal volume reduction is a pathological hallmark of schizophrenia, the molecular pathway responsible for this degeneration remains unknown. Recent reports have suggested the potential role of impaired blood-brain barrier function in schizophrenia pathogenesis. However, direct evidence demonstrating an impaired BBB function is missing. In this preliminary study, we used immunohistochemistry and serum immunoglobulin G antibodies to investigate the state of BBB function in formalin-fixed postmortem samples from the hippocampus and surrounding temporal cortex of patients with schizophrenia and controls without (...) schizophrenia matched for age, sex, and race. Since a functional BBB prevents the extravasation of IgGs, detection of IgGs in the parenchyma is used as direct evidence of BBB breakdown. We also developed a semi-quantitative approach to quantify the extent of IgG leak and therein BBB breach. Analysis of our immunohistochemistry data demonstrated a significantly higher incidence of IgG leak in patients with schizophrenia compared to controls. Further, BBB permeability was significantly higher in advanced-age patients with schizophrenia than both advanced-age controls and middle-aged patients with schizophrenia. Male patients with schizophrenia also demonstrated a significant increase in IgG permeability compared to control males. Interestingly, the extravasated IgGs also demonstrated selective immunoreactivity for neurons. Based on these observations, we suggest that BBB dysfunction and IgG autoantibodies could be two key missing pathoetiological links underwriting schizophrenia hippocampal damage. (shrink)

MEDIEVAL LOGICS LAMBERT MARIE DE RIJK (ed.), Die mittelalterlichen Traktate De mod0 opponendiet respondendi, Einleitung und Ausgabe der einschlagigen Texte. (Beitrage zur Geschichte der Philosophie und Theologie des Mittelalters, Neue Folge Band 17.) Miinster: Aschendorff, 1980. 379 pp. No price stated. THE SEVENTEENTH CENTURY MARTA FATTORI, Lessico del Novum Organum di Francesco Bacone. Rome: Edizioni dell'Ateneo 1980. Two volumes, il + 543, 520 pp. Lire 65.000. VIVIAN SALMON, The study of language in 17th century England. (Amsterdam Studies in the Theory (...) and History of Linguistic Science, Series 111: Studies in theHistory of Linguistics, Volume 17.) Amsterdam: John Benjamins B.V., 1979.x + 218 pp. Dfl. 65. Theoria cum Praxi. Zum Verhaltnis von Theorie und Praxis im 17. und 18. Jahrhundert. (Akten des 111. Internationalen Leibnizkongress, Hannover, 12. bis 17.November 1977, Band 111: Logik, Erkenntnistheorie, Wissenschaftstheorie, Metaphysik, Theologie.) Wiesbaden: Franz Steiner Verlag, 1980. vii + 269 pp. DM 48. CLASSICAL AND NON-CLASSICAL LOGICS MICHAEL CLARK, The place of syllogistic in logical theory. Nottingham: University of Nottingham Press, 1980. ix + 151 pp. £3.00. A.F. PARKER-RHODES, The theory of indistinguishables. Dordrecht, Boston and London: D. Reidel Publishing Company, 1981. xvii + 216 pp. Dfl.90.00/$39.50. NICHOLAS RESCHER and ROBERT BRANDOM, The logic of inconsistency. Oxford:Basil Blackwell, 1980. x + 174 pp. f 11.50. MISCELLANEOUS J. ZELENY, The logic of Marx. Translated from the German by T. Carver. Oxford: Basil Blackwell, 1980. xcii + 247 pp. £12.50. FELIX KAUFMANN, The infinite in mathematics. Edited by Brian McGuinness. Introduction by E. Nagel. Translation from the German by Paul Foulkes. Dordrecht: Reidel, 1978. xvii + 235 pp. Dfl 85/$39.50 (cloth); Dfl 45/$19.95 (paper). PAMELA MCCORDUCK, Machines who think. San Francisco: W.H. Freeman and Company, 1979. xiv + 275 pp. $14.95. J. MITTELSTRASS (ed.), Enzyklopadie Philosophie und Wissenschaftstheorie Bd. 1 : A-G. Mannheim, Wien, Ziirich: Bibliographisches Institut, 1980. 835 pp. DM 128. (shrink)

This volume presents, for the first time, an assemblage of contributions on the philosophical dimensions of the impersonal, the multiplicity of its linguistic, social, scientific, religious and artistic perspectives, as well as initial approaches to its unified definition. Linguistic and logical impersonality The “It" in K. Kraus “Impersonality” in the subject and in events The impersonal ontology of H. Rombach Levinas on the “Il y a” Organisation in non-egological consciousness The witness of consciousness in the Vedānta traditions Anonymous self-consciousness G. (...) Deleuzes figures of the impersonal The impersonal in G. Agamben's Philosophy Formal and collective thought in Spinoza Cusanus and the person as stake in the game of life Impersonal subjectivity and the comedy of solipsism Dimensions of the impersonal in T. Nagel, E. Husserl and H. Plessner On the figure of the impersonal in the Anthropocene Language and mask in F. Nietzsche Theodoros Terzopoulos on impersonality and theatre With contributions by Michael Astroh, Eric Ebner, Eric Eggert, Rolf Elberfeld, Katrin Felgenhauer, Ralf Gisinger, Annika Hand, Stefan Lang, Robert Lehmann, Enrico Müller, Daniel Neumann, Frank Raddatz, Christian Rößner, Thomas Schmaus, Fabian Strobel and Theodoros Terzopoulos. (shrink)

This is the 8th edition of the book, with eight new essays to the volume. Table of contents: Are We Having Sex Now or What? (Greta Christina); Sexual Perversion (Thomas Nagel); Plain Sex (Alan Goldman); Sex and Sexual Perversion (Robert Gray); Masturbation and the Continuum of Sexual Activities (Alan Soble); Love: What’s Sex Got to Do with It? (Natasha McKeever); Is “Loving More” Better? The Values of Polyamory (Elizabeth Brake); What Is Sexual Orientation? (Robin Dembroff); Sexual Orientation: What Is (...) It? (Kathleen Stock); Asexuality (Luke Brunning and Natasha McKeever); LGBTQ ... Z? (Kathy Rudy); How to Be a Pluralist About Gender Categories (Katharine Jenkins); The Negotiative Theory of Gender Identity and the Limits of First-Person Authority (Burkay Ozturk); Racial Sexual Desires (Raja Halwani); Sex and Technology: The Ethics of Virtual Connection (Neil McArthur); A Realist Sexual Ethics (Micah Newman); Sexual Morality and the Concept of Using Another Person (Thomas Mappes); Sexual Use (Alan Soble); Dark Desires (Seiriol Morgan); The Harms of Consensual Sex (Robin West); Casual Sex, Promiscuity, and Objectification (Raja Halwani); Is Prostitution Harmful? (Ole Martin Moen); BDSM (Shaun Miller); Two Views of Sexual Ethics: Promiscuity, Pedophilia, and Rape (David Benatar); Sexual Gifts and Sexual Duties (Alan Soble); A Bibliography of the Philosophy of Sex . (shrink)

Natural selection is commonly interpreted as the fundamental mechanism of evolution. Questions about how selection theory can claim to be the all-sufficient explanation of evolution often go unanswered by today's neo-Darwinists, perhaps for fear that any criticism of the evolutionary paradigm will encourage creationists and proponents of intelligent design.In Biological Emergences, Robert Reid argues that natural selection is not the cause of evolution. He writes that the causes of variations, which he refers to as natural experiments, are independent of (...) natural selection; indeed, he suggests, natural selection may get in the way of evolution. Reid proposes an alternative theory to explain how emergent novelties are generated and under what conditions they can overcome the resistance of natural selection. He suggests that what causes innovative variation causes evolution, and that these phenomena are environmental as well as organismal.After an extended critique of selectionism, Reid constructs an emergence theory of evolution, first examining the evidence in three causal arenas of emergent evolution: symbiosis/association, evolutionary physiology/behavior, and developmental evolution. Based on this evidence of causation, he proposes some working hypotheses, examining mechanisms and processes common to all three arenas, and arrives at a theoretical framework that accounts for generative mechanisms and emergent qualities. Without selectionism, Reid argues, evolutionary innovation can more easily be integrated into a general thesis. Finally, Reid proposes a biological synthesis of rapid emergent evolutionary phases and the prolonged, dynamically stable, non-evolutionary phases imposed by natural selection. (shrink)

The ontological status of sport: Weiss, P. Records and the man. Schacht, R. L. On Weiss on records, athletic activity, and the athlete. Fraleigh, W. P. On Weiss on records and on the significance of athletic records. Stone, R. E. Assumptions about the nature of movement. Suits, B. The elements of sport. Kretchmar, S. Ontological possibilities: sport as play. Morgan, W. An existential phenomenological analysis of sport as a religious experience. Fraleigh, W. P. The moving "I." Fraleigh, W. P. Some (...) meanings of the human experience of freedom and necessity in sport. Keenan, F. W. The concept of doing.--The ethical status of sport: Keating, J. W. The ethics of competition and its relation to some moral problems in ahtletics. Sadler, W. A., Jr. A contextual approach to an understanding of competition: a response to Keating's philosophy of athletics. Osterhoudt, R. G. On Keating on the competitive motif in athletics and playful activity. Suits, B. The grasshopper: a thesis concerning the moral idea of man. Broekhoff, J. Sport and ethics in the context of culture. Zeigler, E. F. The pragmatic (experimentalistic) ethic as it relates to sport and physical education. Roberts, T. J. and Galasso, P. J. The fiction of morally indifferent acts in sport. Osterhoudt, R. G. The Kantian ethic as a principle of moral conduct in sport and athletics. Thomas, C. E. Do you "wanna" bet: an examination of player betting and the integrity of the sporting event.--The aesthetic status of sport: Kuntz, P. G. The aesthetics of sport. Keenan, F. W. The athletic contest as a "tragic" form of art. Osterhoudt, R. G. An Hegelian interpretation of art, sport, and athletics. (shrink)

This book demonstrates that the state-contingent approach provides the best way to think about all problems in the economics of uncertainty, including problems...

The six essays in this volume discuss philosophical thought on scientific theory including: a call for a realist, rather than instrumentalist interpretation of science; a critique of one of the core ideas of positivism concerning the relation between observational and theoretical languages; using aerodynamics to discuss the representational aspect of scientific theories and their isomorphic qualities; the relationship between the reliability of common sense and the authenticity of the world view of science; removing long-held ambiguities on the theory of inductive (...) logic; and the relationship between the actuality of conceptual revolutions in the history of science and traditional philosophical pictures of scientific theory-building. (shrink)

Turnbull offers a close and detailed reading of the Parmenides, using his interpretation to illuminate Plato's major late dialogues. The picture presented of Plato's later philosophy is plausible, highly interesting, and original.

This volume centers on philosophical issues of the life sciences, particularly genetics and psychology, and the relevance of statistical data as the foundation for inductive reasoning in areas such as vaccination testing, population genetics, evolutionary theory, and natural selection. Also discussed is the role of psychology in defining thought processes, experiences, and behaviors and their subsequent relation to scientific discovery, and advancing knowledge of the human condition and human potential.

I believe observation is valued by scientists because it is an objective source of information. Objective here can mean two things. First, observation could be objective in that it is an assured source of truths about the world, truths whose meaning is the same for everyone regardless of their personal theoretical vantage points. I criticize this construal of observational objectivity in chapter one. The guilty doctrine, which I entitle 'empiricistic epistemological foundationalism', is shown to be untenable on, in part, historical (...) grounds. The historical episode I deploy for this task is the early stages of quantum theory, an episode I return to at various times throughout the thesis in illustration of my philosophical points. The sense of objective I favour views empirical data as the locus of extensive interpersonal agreement. Observation, from this perspective, plays the role of a communal judge in arbitrating our theoretical disputes. Returning to early quantum theory , I show how observation could not have had the adjudicative effect it exhibited unless it were objective in this sense. ;A crucial philosophical problem I take up is to provide the best definition of observation suited to accomplish the normative goals set out above for empirical data. Two major contenders are presented in chapter two, the semantic and pragmatic theories of observation, and other pragmatically-based proposals are discussed at the end of chapter four. In the end, I show that the pragmatic theory of observation triumphs as the philosophically most responsible account of the value of scientific observations. ;The final chapter turns to an examination of the bearing of evidence on theory. From my particular pragmatic viewpoint, I describe first how the rationality of induction can be established, and following this I reassess the value of Hempel's classic list of confirmation principles. My final task is to use a new, overtly pragmatic definition of confirmation to re-evaluate the experimental confirmation by Rubens and Kurlbaum of Planck's quantum hypothesis. (shrink)

Introduction -- Reconstructing Nīsābūrī's early education -- Nīsābūrī's early scientific thought -- Nīsābūrī's early religious thought -- Astrology motivating inductions about God's power -- Nīsābūrī's later scientific thought -- The impact of science on Nīsābūrī's religious thought -- The limits of science's influence on Nīsābūrī's religious thought -- Conclusion.

First published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

Identifying Consumption illustrates how an individual’s buying habits are shaped by the dynamics of the consumer marketplace—and thus how consumption and identity inform each other. Robert Dunn brings together the various theories of spending and develops a mode of analysis concentrating on the individual subjectivity of consumption. By doing so, he addresses how we spend and its relationship with status and lifestyle. Dunn provides a comprehensive guide to the study of modern consumer behavior before summarizing and critiquing the major (...) theories of consumption. At this juncture, he proposes a method of analysis that focuses on the significance of status and lifestyle in social relations that can help explain how the consumer marketplace is shaped. He concludes by raising issues about different ways of consuming and the relationship between consumption and identity. (shrink)

The revolution involving the foundations of the physical sciences heralded by relativity and quantum theories has been stimulating philosophers for many years. Both of these comprehensive sets of concepts have involved profound challenges to traditional theories of epistemology, ontology, and language. This volume gathers six experts in physics, logic and philosophy to discuss developments in space exploration and nuclear science and their impact on the philosophy of science.

This bibliography covers writers in both the ordinary language and formal language wings of 20th-century analytic philosophy from 1940 to 1996. A wide range of topics is covered, from the nature of religion as a human activity to various doctrines about the nature of God. More than 5,000 items are listed, with many of them cross-indexed.The bibliography is topically organized into sixteen main categories, with approximately 80 subject headings used to further organize the material. An author index completes the bibliography.

How do thought and language manage to be 'about' aspects of the world? J. Robert G. Williams investigates how representation arises out of a fundamentally non-representational world, showing the explanatory relations between the representational properties of language, of thought, and of perception and intention.

The post-Darwinian double-aspect theory that Professor Robert Kunzendorf's introduces in On the Evolution of Conscious Sensation, Conscious Imagination, and Consciousness of Self points to evolutionary functions of certain sensations, youngling vivid images, and self-consciousness.

Much more than an obligation to protect our clients' rights, ethics is better understood as the very fabric that underpins and supports our most basic efforts in working with clients and interacting with others in our everyday lives. Robert Lee brings together a diverse group of voices in the Gestalt field to demonstrate the interrelations between the ethics of the therapeutic endeavor and the Gestalt tradition, from theory to practice to extensions beyond the analytic setting.

Significant to Dunn's critique of poststructuralist and postmodern theories is his application of George Herbert Mead as a means of theorizing identity and difference. The focus on postmodernity, rather than postmodernism grounds his analysis of identity and difference both materially and socially.

Recent scholarship (by mainly Michael Friedman, but also by Thomas Uebel) on the philosophy of Rudolf Carnap covering the period from the publication of Carnap’s’ 1928 book Der Logische Aufbau der Welt through to the mid to late 1930’s has tended to view Carnap as espousing a form of conventionalism (epitomized by his adoption of the principle of tolerance) and not a form of empirical foundationalism. On this view, it follows that Carnap’s 1934 The Logical Syntax of Language is the (...) pinnacle of his work during this era, this book having developed in its most complete form the conventionalist approach to dissolving the pseudoproblems that often attend philosophical investigation. My task in this paper, in opposition to this trend, is to resuscitate the empiricist interpretation of Carnap’s work during this time period. The crux of my argument is that Carnap’s 1934 book, by eschewing for the most part the empiricism he espouses in the Aufbau and in his 1932 The Unity of Science, is led to a form of conventionalism that faces the serious hazard of collapsing into epistemological relativism. My speculation is that Carnap came to recognize this deficiency in his 1934 book, and in subsequent work (“Testability and Meaning”, published in 1936/37) felt the need to re-instate his empiricist agenda. This subsequent work provides a much improved empiricist epistemology from Carnap’s previous efforts and, ashistory informs us, sets the standard for future research in the theory of confirmation. (shrink)